The Therapeutic Value of Exosomes in Regenerative Aesthetics

A clinician performing a treatment on a woman’s face
Reading Time: 3 Minutes
Author: Patricia Pezzano

The world of regenerative aesthetics is always changing.

While injectable Botox and dermal fillers are here to stay, regenerative aesthetics have become increasingly popular in recent years. This is an approach that taps into your body’s own natural healing powers to work wonders. But how?

Enter exosomes. Once thought of as cellular waste, these tiny extracellular vesicles are proving to be game-changers in skincare and aesthetics. Keep reading to learn about them, their value, and what it all means.

What Are Exosomes?

So, what are exosomes? They are incredibly small structures (imagine mini-containers) created by the cells in your body. They function like the cell’s communication system, ferrying a mix of molecules—such as proteins, fats, and RNA—from one cell to another.

Far from just being a biological curiosity, exosomes play a crucial role in intercellular communication and coordinating activities. They are often considered the messengers of the cellular world, circulating information to keep everything running smoothly.

Exosomes also play a role in stimulating immune responses. They do this by presenting certain peptides to T-cells and transferring antigens to dendritic cells, among other mechanisms. Without getting too deep into cellular biology, these mechanisms are all involved in triggering the aforementioned response in the immune system.

Beyond facilitating cell-to-cell communication and immune responses, exosomes have also shown exciting promise in aesthetic medicine, particularly for skin rejuvenation and wound healing. They reduce inflammation and redness, accelerate healing after laser and microneedling, and reduce the tendency for fibrosis and thick hypertrophic scar formation when used topically.

By teaming up with these tiny but mighty exosomes, regenerative aesthetics offers a fresh, effective way to restore a youthful glow and smooth out wrinkles. It perfectly blends the body’s natural abilities along with cutting-edge science, and is setting a new standard for what is possible in aesthetic treatments.

Woman getting a facial treatment from a woman wearing pink gloves

Benefits of Exosomes

Exosomes are more than just cellular couriers; they have immense therapeutic value, particularly in the world of regenerative aesthetics. Let’s take a look at the scientific mechanisms at play with exosomes.

Skin Rejuvenation

Exosomes encourage collagen production to make skin look younger and fresher. As we age, our skin loses its natural ability to regenerate due to a decrease in human dermal fibroblasts (HDFs). However, exosomes derived from HDFs can amp up collagen production and even control the enzymes that destroy skin structure.

Wound Healing

Adipose-derived stem cell exosomes have been shown to promote collagen synthesis and deposition by activating the P13 Kinase Akt signalling pathway. This, in turn, can shorten healing time and reduce scar formation.


Some exosomes have been associated with alleviating human dermal fibroblast (HDF) senescence and stimulating HDF migration. This, when combined with their inhibitory effect on senescence-related protein expression, gives them anti-aging capabilities.

Woman fresh from the shower, drying her face with a towel

How Exosome Treatments Work

There are several different methods in which exosomes can be applied, each with different benefits depending on the concern being treated. The most common applications are topically, via microneedling or laser resurfacing. Always be sure to perform a skin assessment before administering treatment or receiving it.


Exosomes can be applied topically through creams or serums. It’s important to note that these must be massaged into the skin, as the exosomes need to penetrate the surface in order to communicate with the skin cells and trigger desired biological functions.


Exosomes can also be applied in conjunction with microneedling. Microneedling creates microchannels in the skin through which exosomes can enter, once the treatment has been completed. This method enhances results and improves recovery.

Safety Considerations

Exosomes are generally considered safe. However, they are still a relatively new phenomenon in the world of aesthetics, thus even the experts do not know everything about them and how they interact with the human body.

Learn From the Best at APT Injection Training

Whether you’re looking to learn more about the value of exosomes in regenerative aesthetics or perfect your injection skills with tried-and-true dermal fillers, consider APT Injection Training.

All of our in-person courses are held at our facility in Oakville, Ontario. Here, you will learn from the best and get the hands-on experience you need, whether you are beginning your journey as an injector or seeking to elevate your skills.

Contact us today to get started!

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